Murine thrombopoietin mRNA levels are modulated by platelet count
نویسندگان
چکیده
منابع مشابه
Murine thrombopoietin mRNA levels are modulated by platelet count.
The activity of the c-Mpl ligand hematopoietic progenitors meets criteria expected for thrombopoietin (TPO). Bio-assays have shown that blood TPO levels are inversely related to platelet mass. We sought to identify the molecular basis for this regulation. To determine if TPO mRNA levels respond to platelet demand, RNA from selected organs of mice with high, normal or low platelet counts was sub...
متن کاملRAPID COMMUNICATION Murine Thrombopoietin mRNA Levels Are Modulated by Platelet Count
The activity of the c-Mpl ligand on hematopoietic progenitors meets criteria expected for thrombopoietin (TPO). Bioassays have shown that blood TPO levels are inversely related to platelet mass. We sought to identify the molecular basis for this regulation. To determine if TPO mRNA levels respond to platelet demand, RNA from selected organs of mice with high, normal, or low platelet counts was ...
متن کاملHuman plasma thrombopoietin levels are regulated by binding to platelet thrombopoietin receptors in vivo.
BACKGROUND Data from several studies support the hypothesis that thrombopoietin (TPO) plasma levels are regulated via circulating platelet (PLT) numbers by binding to PLT TPO receptors (TPO-Rs). In this study, PLT numbers and TPO plasma levels were measured following the transfusion of unmanipulated, sham-saturated, and TPO-R-saturated PLT preparations to provide additional in vivo evidence for...
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ژورنال
عنوان ژورنال: Blood
سال: 1995
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v86.10.3668.bloodjournal86103668